Abstract: ObjectiveTo study the expression of tumor metastasis related gene MTA1 and stem cell transcription factor SOX2 in esophageal cancer tissue, the correlation of MTA1 and SOX2, as well as the relationship between them and prognosis, and to provide a theoretical basis for clinical early diagnosis and prognosis.MethodsThe expression of MTA1 and SOX2 were detected with immunocytochemistry, Real-time PCR, Western blot method in 144 samples of esophageal carcinoma tissues. Combined with follow-up data more than 10 years, the relationship between the expression of MTA1 and SOX2, the correlation with clinical pathologic features as well as its relationship with prognosis were analyzed.ResultsThe result showed that both MTA1 and SOX2 were expressed in the cell nucleus of esophageal cancer. The negative or weakly positive rate, moderate positive rate and strong positive rate was 58.34%, 27.08% and 14.58% respectively in MTA1 expression, and was 65.28%, 22.92% and 11.81% respectively in SOX2 expression. The expression of both MTA1 and SOX2 were related to T staging and clinical stage in esophageal cancer tissues, and negative correlated with overall survival span in esophageal cancer cases.ConclusionsTumor metastasis related factors MTA1 and stem cell transcription factor SOX2 were expressed with different degrees in esophageal cancer tissues, and there was correlation between them. The high expression of MTA1 and SOX2 simultaneously in esophageal cancer tissues were associated with poor prognosis.
陈伟妍，李桂艳，辛春，付勇强，付春子. 食管癌组织中MTA1、SOX2的表达及与预后的关系研究[J]. 中国现代手术学杂志, 2017, 21(4): 251-256.
CHEN Wei-yan. The Expression of MTA1and SOX2in Esophageal Cancer Tissues and the Relationship between MTA1,SOX2andPrognosis. Chinese Journal of Modern Operative Surgery, 2017, 21(4): 251-256.
Correction: Identification of Pax5 as a target of MTA1 in B-cell lymphomas[J]. Cancer Res, 2015, 75(12):2580-2581. doi: 10.1158/0008-5472.CAN-15-1095.|
[3]
Alqarni SS, Murthy A, Zhang W, et al. Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex[J]. J Biol Chem, 2014, 289(32):21844-21855. doi: 10.1074/jbc.M114.558940.|
[4]
Boumahdi S, Driessens G, Lapouge G, et al. SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cellcarcinoma[J]. Nature, 2014, 511(7508):246-250. doi: 10.1038/nature13305.|
[5]
Justilien V, Walsh MP, Ali SA, et al. The PRKCI and SOX2 oncogenes are coamplified and cooperate to activateHedgehog signaling in lung squamous cell carcinoma[J]. Cancer Cell, 2014, 25(2):139-151. doi: 10.1016/j.ccr.2014.01.008.|
Vanner RJ, Remke M, Gallo M, et al. Quiescent Sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma[J]. Cancer Cell, 2014, 26(1):33-47. doi: 10.1016/j.ccr.2014.05.005. |
Iijima Y, Seike M, Noro R, et al. Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous cell carcinoma[J]. Int J Oncol. 2015 Feb;46(2):505-12. doi: 10.3892/ijo.2014.2742. |
[17]
Watanabe H, Ma Q, Peng S, et al. SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas[J]. J Clin Invest, 2014, 124(4):1636-1645. doi: 10.1172/JCI71545. |
[18]
Fang L, Zhang L, Wei W, et al. A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation[J]. Mol Cell, 2014, 55(4):537-551. doi: 10.1016/j.molcel.2014.06.018. |
Nagaraj SR, Shilpa P, Rachaiah K, et al. Crosstalk between VEGF and MTA1 signaling pathways contribute to aggressiveness of breast carcinoma[J]. Mol Carcinog, 2015, 54(5):333-350. doi: 10.1002/mc.22104. |
[23]
Zhang J. Correlation of MTA1 and prognosis in colon cancer tissues[J]. Oncology Progress, 2012, 52(7):373-380.|
[24]
Zhou N, Wang H, Liu H, et al. MTA1-upregulated EpCAM is associated with metastatic behaviors and poor prognosis in lung cancer[J]. J Exp Clin Cancer Res, 2015, 34:157. doi: 10.1186/s13046-015-0263-1. |
2017, Vol. 21 
