斑蝥酸钠维生素B6注射液在消化道肿瘤术后的应用

doi:10.16260/j.cnki.1009-2188.2017.06.004

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摘要目的探究斑蝥酸钠维生素B6注射液对消化道肿瘤切除手术术后患者免疫功能的影响。方法将120例消化道肿瘤术后患者随机分成两组，每组60例。观察组在常规治疗的基础上,联合使用斑蝥酸钠维生素B6注射液，静脉滴注，30 ml加入5%葡萄糖注射液250 ml， 1次/d，疗程3周。对照组用法同观察组，但仅含维生素B6。两组在术前、术后4、8 d分别检测免疫球蛋白IgA、IgG、IgM、补体C3、C4和T细胞亚群(CD3、CD4、CD8、CD4/CD8)。结果术后4 d两组IgA、IgG、IgM、补体C3、C4和CD3、CD4、CD8、CD4/CD8较术前均下降(P<0.05)，而两组间比较无明显差异(P>0.05)；术后8 d观察组IgA、IgG、IgM、补体C3、C4和CD3、CD4、CD8、CD4/CD8恢复更快，与对照组相比差异有统计学意义(P<0.05)。结论消化道恶性肿瘤术后应用斑螯酸钠维生素B6注射液可逐渐改善机体的免疫功能。

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	蒋立新

关键词: 斑螯酸钠维生素B6注射液消化道肿瘤免疫功能

Abstract: ObjectiveTo explore the sodium cantharidate vitamin B6 injection on the immune functions in patients with gastrointestinal tumor resection surgery.Methods120 patients with gastrointestinal tumor surgery were randomly divided into two groups, with 60 cases in each. The experimental group was intravenously injected with sodium cantharidate vitamin B6 injection everyday for 3 weeks, with 30 ml in 5% glucose 250 ml. The control group was given vitamin B6 injection instead of the sodium cantharidate vitamin B6 injection. The concentrations of IgA, IgG, IgM, C3, C4, CD3, CD4, CD8, CD4/CD8 of the two groups were detected on the day before operation and 4-day and 8-day after operation.ResultsComparing with the pre-operative one, the levels of 4-day post-operative IgA,IgG,IgM,C3,C4,CD3, CD4, CD8, CD4/CD8 decreased in both two groups (P<0.05). But there was no difference between the two groups(P>0.05). And the levels of 8-day post-operative IgA, IgG, IgM, C3,C4,CD3,CD4,CD8,CD4/CD8 in the experimental group were higher than the control group (P<0.05).ConclusionSodium cantharidate vitamin B6 injection can improve the immune functions gradually in the patients with gastrointestinal tumor surgery.

Key words: sodium cantharidate vitamin B6 injection gastrointestinal neoplams immune function

发布日期: 2018-05-28 期的出版日期: 2017-12-26

ZTFLH:

R735

作者简介: 蒋立新，男,49岁，南京中医药大学江阴附属医院普外科主任中医师。

引用本文:

蒋立新. 斑蝥酸钠维生素B6注射液在消化道肿瘤术后的应用[J]. 中国现代手术学杂志, 2017, 21(6): 413-415.
JIANG Li-xin. The Application of Sodium Cantharidate Vitamin B6Injection after Gastrointestinal Tumor Surgery. Chinese Journal of Modern Operative Surgery, 2017, 21(6): 413-415.

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http://www.surgerychina.com/CN/10.16260/j.cnki.1009-2188.2017.06.004 或 http://www.surgerychina.com/CN/Y2017/V21/I6/413

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