钻孔尿激酶注入引流联合阿托伐他汀钙治疗慢性硬膜下血肿的临床研究

doi:10.16260/j.cnki.1009-2188.2017.05.018

Chinese Journal of Modern Operative Surgery

2017, Vol. 21

Issue (5): 398-400,0 DOI: 10.16260/j.cnki.1009-2188.2017.05.018

Clinical Research

Clinical Research of Urokinase Injection Following Punch Drainage Combined with Oral Atorvastatin Calcium in the Treatment of Chronic Subdural Hematoma

ZHANG Lei1, HOU Meiying2, CHENG Gang3, GUO Yimin1

1. Department of Neurosurgery, Hengshui Second People's Hospital, Hengshui 053000, Hebei, China； 2. Department of Imaging, Hengshui Second People's Hospital, Hengshui 053000, Hebei, China；3. Department of Urological Surgery, Hengshui Second People's Hospital, Hengshui 053000, Hebei, China

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Abstract ObjectiveTo investigate the efficacy and prognosis of urokinase injection following punch drainage combined with oral atorvastatin calcium in the treatment of chronic subdural hematoma.MethodsFrom January 2014 to December 2016, a total of 230 patients with chronic dural hematoma were enrolled in this study, and were randomly divided into the study group and the control group, with 115 cases in each. The patients in the control group were treated with drilling and drainage only. And the study group was given urokinase injection following punch drainage combined with oral atorvastatin calcium. The curative effect, hematoma recurrence, complications, hospitalization time and the hospital costs were observed between the two groups.ResultsThe total effective rate was 96.65% in the study group and was better than 84.35% of the control group. The hematoma recurrence rate, the total complication rate, hospitalization time and hospitalization cost were lower in the study group than that of the control group (P<0.01).ConclusionIt is effective and safe of the urokinase injection following punch drainage combined with oral atorvastatin calcium for the treatment of chronic subdural hematoma, with the advantages of less hematoma recurrences, less complications, less hospitalization time and less hospitalization costs. It is worthy of clinical application and promotion.

Key words： hematoma， subdural drainage urokinase atorvastatin calcium

Published: 25 May 2018

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	张蕾1，侯梅英2，程刚3，国义民1

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张蕾1，侯梅英2，程刚3，国义民1. Clinical Research of Urokinase Injection Following Punch Drainage Combined with Oral Atorvastatin Calcium in the Treatment of Chronic Subdural Hematoma[J]. Chinese Journal of Modern Operative Surgery, 2017, 21(5): 398-400,0.

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http://www.surgerychina.com/EN/10.16260/j.cnki.1009-2188.2017.05.018 OR http://www.surgerychina.com/EN/Y2017/V21/I5/398

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