结直肠癌NOSE术对患者氧化应激、免疫功能及机体微炎症的影响

doi:10.16260/j.cnki.1009-2188.2017.01.003

Chinese Journal of Modern Operative Surgery

2017, Vol. 21

Issue (1): 9-13 DOI: 10.16260/j.cnki.1009-2188.2017.01.003

Clinical Research

Effects on Oxidative Stress Reaction, Immune Function and Inflammation during NOSE Radical Surgery for Colorectal Cancer

DING Haitao, PAERHATI•Abudureyimu, HAN Zhijun, CAO Jie, DiMiLa

Department of General Surgery, Sixth Affiliated Hospital, Xinjiang Medical University, Urumqi 830002, Xinjiang, China

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Abstract ObjectiveTo explore the effect of oxidative stress reaction, immune function and inflammation during the natural orifice specimen extraction (NOSE) radical surgery for the patients with colorectal cancer.MethodsA total of 120 colorectal cancer cases from January 2014 to December 2015 in our hospital were divided into observation group and control group according to random digits table, with 60 cases for each. NOSE surgery was performed in the observation group, and conventional laparoscopic radical resection of colorectal cancer was carried out in the control group. The perioperative index of intraoperative blood loss, operation time, VAS score of 1st day after the surgery, postoperative exhaust time, postoperative hospital stay were compared between two groups. The oxidative stress reaction index (SOD、MDA), inflammatory factors（CRP，TNFα，IL6，IL10） and immune function index （NK，CD3+，CD4+，CD4+/CD8+，IgG，IgM，IgA）were determined and compared.ResultsThe VAS score of 1 day after the operation was lower, and both the gastrointestinal recovery time and hospital stays were shorter in the observation group than those in the control group, the differences were statistical significance (P＜0.05). There was no statistical difference in intraoperative blood loss and operation time between two groups （P＞0.05）. In both observation and control groups: The SOD of both T2 and T3 was lower than that of T1, and the SOD of T3 was higher than that of T2（P＜0.05）. The MAD、CRP、TNFα and IL6 were higher and IL10 was lower at the time point of T2 and T3 than those of T1, and MDA、 CRP、TNFα、IL6 was lower and IL10 was higher at T3 than those at T2（P＜0.05）. The CD3+, CD4+, IgM and IgA of both T2 and T3 were lower than those of T1, and the CD3+, CD4+, IgM and IgA of T3 were higher than those of T2 （P＜0.05）. In group comparison: There was no statistical difference in all indexes of T1 between two groups（P＞0.05）. Compared to the control group, the SOD, IL10, CD3+, CD4+ and IgM was higher and MAD, CRP, TNFα and IL6 was lower in the observation group at the time point of T2 and T3 （P＜0.05）.ConclusionCompared with the traditional laparoscopic radical resection, the NOSE radical resection can effectively relieve the oxidative stress reaction, reduce the micro inflammatory factors release, and lessen immune function impact for colorectal cancer.

Key words： natural orifice specimen extraction (NOSE) radical resection of colorectal cancer colorectal neoplasms oxidative stress;immune function inflammatory reaction

Received: 17 October 2016 Published: 25 May 2018

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	丁海涛，帕尔哈提?阿布都热衣木，韩智君，曹杰，迪米拉

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丁海涛，帕尔哈提?阿布都热衣木，韩智君，曹杰，迪米拉. Effects on Oxidative Stress Reaction, Immune Function and Inflammation during NOSE Radical Surgery for Colorectal Cancer[J]. Chinese Journal of Modern Operative Surgery, 2017, 21(1): 9-13.

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http://www.surgerychina.com/EN/10.16260/j.cnki.1009-2188.2017.01.003 OR http://www.surgerychina.com/EN/Y2017/V21/I1/9

［1］	陈创奇. 腹腔镜下乙状结肠癌根治术经自然腔道(阴道)取出标本［J］. 消化肿瘤杂志(电子版)，2016，8（1）:5355.
［2］	胡俊杰，魏少忠，熊治国，等. 结直肠癌NOSE术的近期效果及对机体细胞免疫功能影响的研究［J］. 中华结直肠疾病电子杂志，2016，5（4）:323327.
［3］	闫军，李亮，陈曦. 腹腔镜下直肠癌根治术与开腹手术近期疗效及对机体免疫功能的影响［J］. 中国临床研究，2016，29（3）:348350.
［4］	杜建军，王园园，郭雄飞，等. 腹腔镜手术治疗结肠癌的围术期应激反应及免疫功能观察［J］. 结直肠肛门外科，2015，21（6）:413417.
［5］	郭雄飞，杜建军，王园园，等. 单孔腹腔镜根治手术治疗直肠癌对患者围术期应激反应的影响［J］. 结直肠肛门外科，2016，22（1）:3841.
［6］	董纪秀，倪观太. 腹腔镜手术对机体免疫功能和氧化应激的影响［J］. 医学综述，2012，18（10）:15811583.
［7］	谭华勇，潘凯，钟克力. 腹腔镜直肠癌根治术标本取出方法对肛门功能影响的研究［J］. 中华腔镜外科杂志(电子版)，2012，06:446450.
［8］	胡汉卿，刘正，王贵玉，等. 经肛门拖出标本的腹腔镜直肠癌根治术临床分析(附10例报告)［J］. 外科理论与实践，2014，19（6）:517520.
［9］	姜艳辉，曲红梅，孙伟，等. 腹腔镜和开腹结直肠癌根治术对患者机体炎症免疫反应的影响［J］. 实用癌症杂志，2015，30（4）:491493+496.
［10］	崔显念，柳洪周，李宗清，等. 结直肠癌患者脂类水平及氧化应激水平的评价研究［J］. 结直肠肛门外科，2016，22（S1）:12.
［11］	陈铁军，李伟明，周五一，等. 腹腔镜与开腹结直肠癌根治术对机体微炎症和氧化应激影响的比较［J］. 现代消化及介入诊疗，2009，14（3）:141144.
［12］	常东，赵亚双，潘洪志. 结直肠癌患者体内氧化应激状态的评价及产物的分析［J］. 医学研究生学报，2009，22（10）:10391041.
［13］	王隽婕，韩承新，郑皓，等. 腹腔镜和开腹结直肠癌手术对机体免疫功能影响的Meta分析［J］. 中国普通外科杂志，2014，23（2）:217226.
［14］	刘兆龙，龚航军，韩刚，等. 腹腔镜与传统开腹结直肠癌手术对免疫应激的影响［J］. 腹腔镜外科杂志，2014，19（3）:161164.
［15］	汪迎，潘凯，夏利刚，等. 腹腔镜与开腹直肠癌根治术对局部与全身免疫反应影响的对比研究［J］. 中国微创外科杂志，2010，10(7):602605.