The Application of Different Doses of Dexmedetomidine in the Surgery of Selective Posterior Lumbar Rhizotomy for the Treatment of Mixed Dystonia and Spasticity in Children with Cerebral Palsy
Aikebaier•Halike, LU Xia, Mutalifu•Nureihamaiti, XU Jian, YAN Baofeng, Maieraba, XU Jufang
Cerebral Palsy Center,Second Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang, China
Abstract: ObjectiveTo explore the anaesthetic effects and evoked electromyogram results of different doses of dexmedetomidine in the surgery of selective posterior lumbar rhizotomy for the treatment of mixed dystonia and spasticity in children with cerebral palsy.MethodsThere were 60 cases of mixed dystonia and spasticity children with cerebral palsy underwent selective posterior lumbar rhizotomy from February 2015 to March 2016 in our hospital. According to random number table, all the 60 cases were divided into two groups, with 30 cases for each. Two groups of children were given electrophysiological monitoring during operation, in which group A was given 0.5 μg/(kg?min) dexmedetomidine by intravenous infusion, and group B was given 1.0 μg/(kg?min). It was compared respectively between the two groups of operation time, anesthesia time, waking hours, EEMG latency and amplitude of retention rate, mean arterial pressure, heart rate, SpO2 and adverse reactions.ResultsThere was no difference of operation time, anesthesia time and the waking hours (P>0.05). There was no difference of the EEMG latency and amplitude of retention rate before and after the dexmedetomidine injection between the two groups (P>0.05). The mean arterial pressure and heart rates of group B was (60.5±5.1 )mmHg and (72.3±10.1) times/minute respectively, which were significantly lower than (63.8±6.6) mmHg and (80.6±12.5) times/min of group A. The differences were statistically significant (all P<0.05). There was no significant difference of the incidence of adverse reactions between the two groups (P>0.05).ConclusionsIt may be the better dose of 0.5μg/(kg?min)of dexmedetomidine in elective posterior lumbar rhizotomy for the treatment of mixed dystonia and spasticity in children with cerebral palsy for more advantages of safety and efficacy.
艾克拜尔•哈里克，逯霞，木塔力甫•努热合买提，许健，闫宝锋，买尔阿芭，许菊芳. 不同剂量右美托咪定在脑瘫患儿选择性腰骶部脊神经后根切断术中的应用[J]. 中国现代手术学杂志, 2017, 21(1): 73-76.
Aikebaier•Halike, LU Xia, Mutalifu•Nureihamaiti, XU Jian, YAN Baofeng, Maieraba, XU Jufang. The Application of Different Doses of Dexmedetomidine in the Surgery of Selective Posterior Lumbar Rhizotomy for the Treatment of Mixed Dystonia and Spasticity in Children with Cerebral Palsy. Chinese Journal of Modern Operative Surgery, 2017, 21(1): 73-76.
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2017, Vol. 21 
