Clinical Research of Urokinase Injection Following Punch Drainage Combined with Oral Atorvastatin Calcium in the Treatment of Chronic Subdural Hematoma
1. Department of Neurosurgery, Hengshui Second People's Hospital, Hengshui 053000, Hebei, China； 2. Department of Imaging, Hengshui Second People's Hospital, Hengshui 053000, Hebei, China；3. Department of Urological Surgery, Hengshui Second People's Hospital, Hengshui 053000, Hebei, China
Abstract: ObjectiveTo investigate the efficacy and prognosis of urokinase injection following punch drainage combined with oral atorvastatin calcium in the treatment of chronic subdural hematoma.MethodsFrom January 2014 to December 2016, a total of 230 patients with chronic dural hematoma were enrolled in this study, and were randomly divided into the study group and the control group, with 115 cases in each. The patients in the control group were treated with drilling and drainage only. And the study group was given urokinase injection following punch drainage combined with oral atorvastatin calcium. The curative effect, hematoma recurrence, complications, hospitalization time and the hospital costs were observed between the two groups.ResultsThe total effective rate was 96.65% in the study group and was better than 84.35% of the control group. The hematoma recurrence rate, the total complication rate, hospitalization time and hospitalization cost were lower in the study group than that of the control group (P<0.01).ConclusionIt is effective and safe of the urokinase injection following punch drainage combined with oral atorvastatin calcium for the treatment of chronic subdural hematoma, with the advantages of less hematoma recurrences, less complications, less hospitalization time and less hospitalization costs. It is worthy of clinical application and promotion.
张蕾1，侯梅英2，程刚3，国义民1. 钻孔尿激酶注入引流联合阿托伐他汀钙治疗慢性硬膜下血肿的临床研究[J]. 中国现代手术学杂志, 2017, 21(5): 398-400,0.
ZHANG Lei1, HOU Meiying2, CHENG Gang3, GUO Yimin1. Clinical Research of Urokinase Injection Following Punch Drainage Combined with Oral Atorvastatin Calcium in the Treatment of Chronic Subdural Hematoma. Chinese Journal of Modern Operative Surgery, 2017, 21(5): 398-400,0.
Oh HJ, Lee KS, Shim JJ, et al. Postoperative course and recurrence of chronic subdural hematoma［J］. J Korean Neurosurg Soc, 2010,48(6):518523. doi: 10.3340/jkns.2010.48.6.518.
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Li Y, Zhang D, Zhang Y, et al. Augmentation of neovascularization in murine hindlimb ischemia by combined therapy with simvastatin and bone marrowderived mesenchymal stem cells transplantation［J］. J Biomed Sci, 2010 ,17:75. doi: 10.1186/142301271775.
2017, Vol. 21 
