Abstract: Objective?To investigate the clinical effect of bilateral internal iliac arterial infusion chemotherapy for treatment of advanced cervical carcinoma.Methods?The clinicaldata of 47 cervical carcinoma cases were reviewed,including 36 of Ⅱb，1of Ⅲa and 10 of Ⅲb according to FIGO staging.There were 46 cases of squamous-celled carcinoma and 1case of adenocarcinoma.The pathological exam revealed poorlydifferentiated in 8 cases,moderatelydifferentiated in 21cases and welldifferentiated in 18 cases.Bilateral internal iliac arterial infusion chemotherapy was performed in all 47 cases,and radicalhysterectomy and pelvic lymph nodedissection was carried out in 22 cases after chemotherapy.The short-term clinical effect,operation rate were observed.The bone marrow suppression and liver and kidney functiondamage were observed before and after chemotherapy.Results?The total remission rate was 76.6%,and the operative rate after chemotherapy was 46.8%.The effective rate washigher in stage Ⅱb than that in stage Ⅲ (χ2=12.241,P=0.001),and the operative rate of stage Ⅱb patients was significantlyhigher than that of stage Ⅲa and Ⅲb patients (χ2=15.032,χ2=13.843,P<0.01).No correlation was found between tumorhistologicaldifferentiation and clinical chemotherapy remission rate in cervical cancer patients (r=0.012,P=0.081).There was a positive correlation between clinical stage and clinical chemotherapy remission rate (r=0.585,P=0.000).The leukocyte (WBC) and platelet (PLT) weredecrease,while alanine aminotransferase (ALT),aspartate aminotransferase (AST),urobilinogen(Ur) and creatinine (Cr) were increased after the chemotherapy (P<0.05).There was no serious adverse reaction after the operation.Conclusion?The bilateral internal iliac arterial infusion chemotherapy can achieve a better clinical effect,high operation rate and less adverse reaction for advanced cervical carcinoma patients,and it is a kind of effective comprehensive therapy.
潘静，姚丽艳，朱晓玉，孙业亮. 中晚期宫颈癌动脉灌注化疗临床疗效分析[J]. 中国现代手术学杂志, 2018, 22(1): 56-60.
PAN Jing. The Clinical Effect Analysis on Bilateral Internal Iliac Arterial Infusion Chemotherapy for AdvancedCervical Carcinoma. Chinese Journal of Modern Operative Surgery, 2018, 22(1): 56-60.
2018, Vol. 22 
