Chinese Journal of Modern Operative Surgery  2017, Vol. 21 Issue (2): 149-152 DOI: 10．16260/j．cnki．1009 －2188．2017．02．017 |
| Clinical Research |
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| The Changes of Serum NSE and TGF-β1 After Selective Posterior Lumbar Rhizotomy for Children with Cerebral Palsy |
| Aikebaier· Halike，LU-Xia，XU-Jian，YAN Bao-Feng，Mutalifu · Nureihamaiti，Maieraba，LUAN Xin-Ping
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| Cerebral Palsy Center，Second Affiliated Hospital，Xinjiang Medical University，Urumqi 830011，Xinjiang，China |
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Abstract ObjectiveTo study the curative effect of the selective posterior lumbar rhizotomy for children with spastic paralysis of the lower extremities spasm and to explore the changes of serum neuron specific enolization enzyme(NSE)and transforming growth factor-beta 1(TGF-β1)．MethodsFrom March 2014 to December 2015，there were 40 children with lower limb spasm underwent selective posterior lumbar rhizotomy．Their Cho/Cr、Cho/NAA、NAA/Cr ratio in the basal ganglia using PRESS135 and PRESS35 sequence，and serum NSE and TGFβ1 level were studied．ResultsAfter operation，the muscle tensions of leg triceps，hamstrings and hip adduction muscles obviously decreased(all P ＜0．05)．Cho/NAA of the contra-lateral basal ganglia region increased，while NAA/Cr decreased simultaneously(P ＜0．05)．The postoperative serum level of NSE was(16．4 ±4．1) μg/L，which was lower than(28．9 ±8．2) μg/L of pre-peration，and TGFβ1 was(32．4 ±24．7)ng/L，which was lower than(64．2 ±31．5)ng/L of pre-peration(P ＜0．05)．ConclusionIt is demonstrated of good clinical effects of the selective posterior lumbar rhizotomy for children with spastic paralysis of the lower extremities spasm，which can both improve the children＇s symptoms，and regulate serum NSE and TGFβ1 levels．
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Received: 09 October 2016
Published: 25 May 2018
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Corresponding Authors:
XU Jian
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| About author:: 许健，男，47岁，新疆医科大学第二附属医院脑瘫中心副主任医师。 |
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