对下肢骨折手术患者围术期不同时间段应用依托考昔术后镇痛效果的评估

doi:10.16260/j.cnki.1009-2188.2017.05.012

Chinese Journal of Modern Operative Surgery

2017, Vol. 21

Issue (5): 371-375 DOI: 10.16260/j.cnki.1009-2188.2017.05.012

Clinical Research

The Analgesic Effects of Different Modes of Etoricoxib Analgesia for Postoperative Patients with Lower Limb Fractures

XIE Zhi-jin1, FANG Yue2

1.Department of Orthopedics, the Seventh People's Hospital of Chengdu, Chengdu 610041, Sichuan, China; 2.Department of Orthopedics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China

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Abstract ObjectiveTo assess the effects of perioperative analgesia of a selective cyclooxygenase 2 inhibitor(COX2),etoricoxib, on pain managements.MethodsA total of 90 patients with lower limb fractures, who admitted to the Department of Orthopedics, the Seventh People's Hospital of Chengdu, from March 2012 to September 2016, were randomly divided into three groups. Group A received etoricoxib 3 days before the surgery. Group B received etoricoxib 2 hours before the surgery on the operation day. Group C received etoricoxib 2 hours after the recovery from anesthesia. Numeric rating scales (NRS) were recorded after the operation. The adverse drug reaction, and the total dosages of pethidine for remedial analgesia after surgery were also recorded.ResultsCompared with Group C, the patients with preemptive analgesia groups (Group A and B)had significantly lower NRS scores at 4h、8h、12h and 24h after the operation(P<0.05), but there was no statistical significance between Group A and B(P>0.05). The consumption of pethidine had no difference between Group A and B either(P>0.05).ConclusionEtoricoxib has a preventive analgesia effect in perioperative analgesia, but there is no significant advantage of the 3day preoperative oral etoricoxib adoption comparing with the 2hour preoperative one.

Key words： analgesia cyclooxygenase2 inhibitor etoricoxib lower limbs fractures

Published: 25 May 2018

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	谢志进1，方跃2

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谢志进1，方跃2. The Analgesic Effects of Different Modes of Etoricoxib Analgesia for Postoperative Patients with Lower Limb Fractures[J]. Chinese Journal of Modern Operative Surgery, 2017, 21(5): 371-375.

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http://www.surgerychina.com/EN/10.16260/j.cnki.1009-2188.2017.05.012 OR http://www.surgerychina.com/EN/Y2017/V21/I5/371

［1］	Yi PH, Haughom BD, Hansen EN. Comment on "perioperative administration of selective cyclooxygenase2 inhibitors for postoperative pain management in patients after total knee arthroplasty"［J］. J Arthroplasty， 2015，30(4):718. doi: 10.1016/j.arth.2014.10.029.
［2］	于浩淼, 白晓东, 马立峰, 等. 环氧化酶2抑制剂帕瑞昔布、塞来昔布在TKA围手术期多模式镇痛中的效果研究［J］. 中华损伤与修复杂志（电子版）,2014,9(6):634639.
［3］	Golubovska I, Miscuks A, Rudzītis Eˉ. Multimedia analgesia in perioperative settings: improvement perspectives［J］. Proc Latv Acad of Sci（Section B）,2014,68(56):222227.
［4］	PogatzkiZahn EM, Zahn PK. From preemptive to preventive analgesia［J］. Curr Opin in Anaesthesiol, 2006, 19(5):551555.
［5］	Sowbhagya LB, Krishna PP, Santhi SM, et al. Comparative study to evaluate the efficacy of etoricoxib vs placebo as preemptive analgesia for acute postoperative pain relief in orthopedic surgeries［J］. J Evol Med Dent Sci，2014,3(30):83338339.
［6］	Rasmussen GL, Malmstrom K, Bourne MH, et al. Etoricoxib provides analgesic efficacy to patients after knee or hip replacement surgery: a randomized, doubleblind, placebocontrolled study［J］. Anesth Analg, 2005,101(4):11041111.
［7］	Lisboa AH, Pilatti GL. Pain control with dexamethasone, etoricoxib or ibuprofen associated with arginine in impacted third molar surgery［J］. Rgo,2013,61(3):335340.
［8］	Sowbhagya LB, Krishna PP, Santhi SM, et al. Comparative study to evaluate the efficacy of etoricoxib vs placebo as preemptive analgesia for acute postoperative pain relief in orthopedic surgeries［J］. J Evol Med Dent Sci, 2014,3(30):83338339.
［9］	Fleckenstein J, Kramer S, Offenbcher M, et al. Etoricoxibpreemptive and postoperative analgesia (EPPA) in patients with laparotomy orthoracotomydesign and protocols［J］. Trials, 2010,11:66. doi: 10.1186/174562151166.
［10］	Boonriong T, Tangtrakulwanich B, Glabglay P, et al. Comparing etoricoxib and celecoxib for preemptive analgesia for acute postoperative pain inpatients undergoing arthroscopic anterior cruciate ligament reconstruction: a randomizedcontrolled trial［J］. BMC Musculoskelet Disord, 2010 ,11:246. doi: 10.1186/1471247411246.
［11］	Brubaker L, Kendall L, Reina E. Multimodal analgesia: A systematic review of local NSAIDs for nonophthalmologic postoperativepain management［J］. Int J Surg， 2016，32:158166. doi: 10.1016/j.ijsu.2016.07.003.
［12］	Cannon CP, Curtis SP, FitzGerald GA, et al. CardioNRScular outcomes with etoricoxib and diclofenac in patients with osteoarthritis andrheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Longterm (MEDAL)programme: a randomised comparison［J］. Lancet, 2006,368(9549):17711781.
［13］	Kearney PM, Baigent C, Godwin J, et al. Do selective cyclooxygenase2 inhibitors and traditional nonsteroidal antiinflammatory drugsincrease the risk of atherothrombosis? Metaanalysis of randomised trials［J］. BMJ, 2006,332(7553):13021308.
［14］	Dajani EZ, Islam K. Cardiovascular and gastrointestinal toxicity of selective cyclooxygenase2 inhibitors in man［J］. J Physiol Pharmacol，2008，59 （Suppl 2）:S117S133.
［15］	Manworren RC. Multimodal pain management and the future of a personalized medicine approach to pain［J］. AORN J， 2015 ，101(3):308314; quiz 3158. doi: 10.1016/j.aorn.2014.12.009.