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Abstract Objective To analyze the relationship of serum brain natriuretic peptide (BNP) and mean pulmonary arterial pressure (mPAP) in three different methods of atrial septal defect procedures. Methods From January, 2015 to June, 2017, 28 cases of atrial septal defects were treated in our hospital. In this study, there were 8 cases repaired with heterologous pericardium patch under CPB(group A), 12 cases were blocked by transthoracic minimal invasive occlusion surgery(group B), and 8 cases blocked by percutaneous trans-jugular vein occlusion surgery(group C). The patients were (17.9± 12.2 )years old with body mass of (44.6±24.8)kg. The BNP concentration was detected on the day before operation, 24 hours after operation, and 3 months after surgery. The mPAP changes were measured as well. Results In group A, it was detected mPAP of (36.2±6.1)mmHg，(35.8±5.3)mmHg and (28.8±4.2)mmHg respectively pre-operatively， 24 hours post-operatively and 3 months post-operatively. And the BNP was (175.2±58.3)pg/ml，(556.5±191.6)pg/ml and(169.0±43.4)pg/ml. In group B, the mPAP was(23.8±4.8)mmHg，(22.3±3.9) mmHg and (22.6±4.5)mmHg respectively, and BNP was (138.5±63.2)pg/ml， (404.6±188.5)pg/ml and (113.0±41.4) pg/ml. In group C, the mPAP was (21.3±5.2) mmHg， (18.8±3.6) mmHg and (17.9±2.7) mmHg， and BNP concentrations was (102.5±78.5) pg/ml， (392.8±263.1) pg/ml and (78.6±35.4)pg/ml respectively. It had significant co-relationship between the BNP and mPAP according to the correlation coefficient analysis(P<0.05). Conclusion In all the 3 groups, it shows significant co-relationships between the BNP concentration and the mPAP.
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Published: 14 August 2018
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Corresponding Authors:
FENG Jia-tao
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2018, Vol. 22 
